| Theme | GIST (gastrointestinal stromal tumor) | |
|---|---|---|
| Title | Pathological Diagnosis of GIST | |
| Publish Date | 2005/08 | |
| Author | Masahiro Ikegami | Department of Pathology, The Jikei University School of Medicine |
| Author | Tomoki Koyama | Department of Pathology, The Jikei University School of Medicine |
| Author | Hirohiko Kobayashi | Department of Pathology, The Jikei University School of Medicine |
| Author | Hironori Ishii | Department of Pathology, The Jikei University School of Medicine |
| Author | Takashi Nikaido | Department of Pathology, The Jikei University School of Medicine |
| Author | Tetsuya Yamada | Department of Pathology, The Jikei University School of Medicine |
| [ Summary ] | Gastrointestinal stromal tumor(GIST) accounts for the overwhelming majority (80 - 90%) of mesenchymal tumors in the gastrointestinal tract. Immunological staining for CD 117 (KIT) and CD 34 is essential for diagnosing GIST, but staining varies at different locations even within the same patient, and final diagnosis is generally made using a surgical specimen. The fact that GIST is latently malignant must be kept in mind. While tumor size, mitotic index and MIB-1 index are useful for assessing malignancy, no absolute indicators have yet been identified. In GIST, combining molecular pathological analysis with histological analysis allows the gathering of clinical data that are extremely useful for not only diagnosis, but also therapy and prognosis. | |