| Theme | Comparison of PPIs and H2RAs in the Actions and Suitable Use for the Diseases | |
|---|---|---|
| Title | Anti-Secretory Therapy for Patients with Endoscopy-Negative Gastro-Esophageal Reflux Disease | |
| Publish Date | 2005/07 | |
| Author | Kyoichi Adachi | Department of Gastroenterology and Hepatology, Shimane University School of Medicine |
| Author | Kenji Furuta | Department of Gastroenterology and Hepatology, Shimane University School of Medicine |
| Author | Masaharu Miki | Department of Gastroenterology and Hepatology, Shimane University School of Medicine |
| Author | Takane Azumi | Department of Gastroenterology and Hepatology, Shimane University School of Medicine |
| Author | Yoshikazu Kinoshita | Department of Gastroenterology and Hepatology, Shimane University School of Medicine |
| [ Summary ] | Cases of endoscopy-negative gastroesophageal reflux disease (GERD) are as frequently observed in Japan, as in Western countries. GERD symptoms in patients with endoscopy-negative GERD are reported to be effectively controlled by initial and maintenance anti-secretory therapy, using H2 receptor antagonists and proton pump inhibitors. However, the efficacy of anti-secretory therapy in patients with endoscopy-negative GERD is reported to be inferior to that in patients with erosive esophagitis. The efficacy of placebo treatment has been demonstrated to be relatively high in patients with endoscopy-negative GERD. GERD symptoms in endoscopy-negative GERD patients may be caused by something besides gastro-esophageal acid reflux, and adequate therapy for patients with endoscopy-negative GERD should be investigated further. | |