| Theme | Comparison of PPIs and H2RAs in the Actions and Suitable Use for the Diseases | |
|---|---|---|
| Title | Comparison of Rebound Phenomenon in H2RAs and PPIs | |
| Publish Date | 2005/07 | |
| Author | Takashi Kobayashi | Department of Internal Medicine, Second Teaching Hospital, Fujita Health University School of Medicine |
| Author | Junji Yoshino | Department of Internal Medicine, Second Teaching Hospital, Fujita Health University School of Medicine |
| Author | Kazuo Inui | Department of Internal Medicine, Second Teaching Hospital, Fujita Health University School of Medicine |
| Author | Takao Wakabayashi | Department of Internal Medicine, Second Teaching Hospital, Fujita Health University School of Medicine |
| Author | Kazumu Okushima | Department of Internal Medicine, Second Teaching Hospital, Fujita Health University School of Medicine |
| Author | Naoki Kamiya | Department of Internal Medicine, Second Teaching Hospital, Fujita Health University School of Medicine |
| [ Summary ] | We produced an outline concerning the intragastric acid rebound phenomenon when cancelling administration of a histamine H2 receptor blocking agent (H2RA) and proton pump inhibitor (PPI). The change produced by a function regulatory mechanism level of histamine receptors seemed to influence acid rebound, which occurred after cancellation of H2RA administration. It was also supposed that acid rebound occuring at night in was a particular cause of ulcer recurrence. On the other hand, in the case of intragastric acid rebound phenomenon with the cancellation of PPI administration, there have been a few reported cases. However, there have been many reports on acid rebound occurring. It seemed that there has been very little likelihood of outbreaks of this phenomenon when using PPIs with normal dosages in Japan. | |