| Theme | Comparison of PPIs and H2RAs in the Actions and Suitable Use for the Diseases | |
|---|---|---|
| Title | The Time to Onset of Action of PPI and H2 Blocker During Their Initial Administration | |
| Publish Date | 2005/07 | |
| Author | Toshihito Saitoh | Departmenf of Internal Medicine, Tokyo Women's Medical University, Daini Hospital |
| Author | Hiroko Otsuka | Departmenf of Internal Medicine, Tokyo Women's Medical University, Daini Hospital |
| Author | Hiroaki Kurai | Departmenf of Internal Medicine, Tokyo Women's Medical University, Daini Hospital |
| Author | Takahiro Kawasaki | Departmenf of Internal Medicine, Tokyo Women's Medical University, Daini Hospital |
| Author | Junko Hirakawa | Departmenf of Internal Medicine, Tokyo Women's Medical University, Daini Hospital |
| Author | Haruki Mori | Departmenf of Internal Medicine, Tokyo Women's Medical University, Daini Hospital |
| [ Summary ] | We evaluated the time to onset of action of PPI and H2 blocker during their initial administration. With intravenous administration, both H2 blocker and omeprazole increased the intragastric pH value to 3.5 within an hour. H2 blocker increased the intragastric pH value in an hour with its oral administration on an empty stomach. When PPI was administrated orally on the H. pylori-positive patients, the required time to increase the intragastric pH value was short. Compared with other two PPIs, rabeprazole was the fastest on the time to onset of action. Also, rabeprazole increased the percent time of the intragastric pH value of 3 or higher from the first day of the administration. The appropriate selection of medicine is essential for the initial treatment of acid-related diseases. | |