| Theme | Oxidative Stress and the Liver | |
|---|---|---|
| Title | Antioxidant Therapy for Liver Disease | |
| Publish Date | 2005/04 | |
| Author | Miwa Kawanaka | Center for Liver Disease, Kawasaki Hospital, Kawasaki Medical School |
| Author | Gotaro Yamada | Center for Liver Disease, Kawasaki Hospital, Kawasaki Medical School |
| [ Summary ] | Oxidative stress (OS) is suspected as an important pathophysiological mechanism in non alcoholic steatohepatitis (NASH) and hepatitis C virus (HCV) infection. Anti-OS therapies in NASH and chronic hepatitis C (CH-C) are introduced. The primary treatment for NASH is weight reduction but the difficult point is maintaining ongoing weight loss. Trials of anti-OS therapies using vitamins E and C are reported to suppress liver injury and hepatic fibrosis in NASH. In CH-C, with no response to anti-viral treatment, anti-OS therapy as well as anti-inflammatory treatments have been tried to treat the progression to cirrhosis and development of hepatocellular carcinoma. |
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