| Theme | H.pylori Negative Upper Gastroenterological Diseases; Increasing of Their Incidence in the 21st Century | |
|---|---|---|
| Title | Reflux Esophagitis | |
| Publish Date | 2004/05 | |
| Author | Tomoyuki Koike | Division of Gastroenterology, Tohoku University Graduate School of Medicine |
| Author | Shuichi Ohara | Division of Gastroenterology, Tohoku University Graduate School of Medicine |
| Author | Yoshifumi Inomata | Division of Gastroenterology, Tohoku University Graduate School of Medicine |
| Author | Katsunori Iijima | Division of Gastroenterology, Tohoku University Graduate School of Medicine |
| Author | Hitoshi Sekine | Division of Gastroenterology, Tohoku University Graduate School of Medicine |
| Author | Tooru Shimosegawa | Division of Gastroenterology, Tohoku University Graduate School of Medicine |
| [ Summary ] | We reported that the prevalence of Helicobacter pylori (H.pylori) infection and the grade of atrophic gastritis were both significantly lower, while acid secretion was significantly greater in the patients with reflux esophagitis than those without it. We also reported that increased gastric acid secretion after H.pylori eradication may explain a reason for the development of reflux esophagitis. Therefore, H.pylori is considered to be a protective factor in the development of reflux esophagitis via the induction of gastric hypose cretion. | |