| Theme | H.pylori Negative Upper Gastroenterological Diseases; Increasing of Their Incidence in the 21st Century | |
|---|---|---|
| Title | Helicobacter pylori-Negative Gastric MALT Lymphoma | |
| Publish Date | 2004/05 | |
| Author | Shotaro Nakamura | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu Universlty |
| Author | Mitsuo Iida | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu Universlty |
| [ Summary ] | The clinicopathologic features of Helicobacter pylori (H.pylori)-negative gastric MALT lymphoma were described. Compared to H.pylori-positive cases, H.pylori-negative gastric MALT lymphomas tend to show deeper invasion of the gastric wall, and have t(11;18)(q 21;q21) or API2-MALT chimeric transcript more frequently. Most cases with H.pylori-negative gastric MALT lymphoma do not respond to eradication therapy except for Helicobacter heilmannii-associated cases. Several histologic features of H.pylori-negative MALT lymphoma have been suggested, including uniform and monotonous proliferation of neoplastic cells mainly in the deep portion of the mucosa, lacking glandular atrophy, intestinal metaplasia, or lymphoepithelial lesions. | |