| Theme | Risk Factors for Gastric Carcinogenesis | |
|---|---|---|
| Title | H.pylori Infection and Gastric Cancer: Hypoacidity and Carcinogenesis | |
| Publish Date | 2004/03 | |
| Author | Akiko Shiotani | Health Administration Center, Wakayama University |
| Author | Mitsutaka Kumamoto | Aishinkai Nakae Hospital |
| Author | Hiroyasu Iishi | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| [ Summary ] | The intestinal type of gastric cancer is preceded by chronic inflammation and atrophic gastritis, which in turn result in impairment of defense mechanisms and additionally induce hypergastrinemia, vitamin C deficiency, excessive reactive oxygen metabolites (ROMs), increase in N-nitroso compounds (NOCs), and epithelial cell proliferation in the stomach. A particular sequence of inflammatory events induced by H.pylori infection probably acts as an initiator of gastric cancer; on the other hand, hypoacidity may act as a key determinant for the alterations and mutations of apoptosis regulating genes, resulting in a loss of balance between apoptosis and cell proliferation. | |