| Theme | Risk Factors for Gastric Carcinogenesis | |
|---|---|---|
| Title | Participation of Genetic Polymorphism and Genetic Instability in Gastric Carcinogenesis | |
| Publish Date | 2004/03 | |
| Author | Shunji Matsumura | Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences |
| Author | Kazuya Kuraoka | Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences |
| Author | Wataru Yasui | Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences |
| [ Summary ] | Cancer develops and progresses due to multiple genetic and epigenetic alterations as a result of the accumulation of various endogenous and exogenous causes. The most important endogenous causes may be genetic polymorphism and the carrying of abnormalities in causative genes for hereditary cancers. Susceptibility to gastric cancer may be associated with genetic polymorphism involved not only in mucosal protection, inflammatory response and metabolic enzymes but, also in cell growth, cell adhesion and matrix degradation. Genetic instability, caused by inactivation of the mismatch repair system is a good marker for development of multiple primary cancers and for prediction of true precancerous lesions in the stomach. These may be the candidate risk factors that will be applied to novel targets for early detection and prevention of gastric cancer. | |