| Theme | Nonalcoholic Steatohepatitis (NASH) | |
|---|---|---|
| Title | Clinical Course of NASH | |
| Publish Date | 2003/08 | |
| Author | Nobuyasu Ito | Departments of Gastroenterology, Mie Prefectural General Medical Center |
| Author | Manabu Tajima | Departments of Gastroenterology, Mie Prefectural General Medical Center |
| Author | Yasuyo Izumi | Departments of Gastroenterology, Mie Prefectural General Medical Center |
| Author | Itsuo Kusano | Departments of Pathology, Mie Prefectural General Medical Center |
| Author | Katsuya Shiraki | First Department of Internal Medicine, Mie University School of Medicine |
| Author | Yukihiko Tameda | First Department of Internal Medicine, Mie University School of Medicine |
| [ Summary ] | Patients with simple fatty livers suggested a benign clinical course but patients with nonalcoholic steatohe patitis (NASH) gradually developed cirrhosis and complications, including liver-related death. The prevalence of obesity and diabetes in patients with cryptogenic cirrhosis was similar to that for NASH patients. Post-orthotopic liver transplantation nonalcoholic fatty liver disease and NASH can be seen in a number of patients with cryptogenic cirrhosis. These facts support the idea that some cases of cryptogenic cirrhosis represent burned-out NASH. Hepatocellular carcinoma (HCC) may represent a late complication of NASH-related cirrhosis and this emphasizes the need for watchful screening for HCC in patients with NASH-related cirrhosis. | |