| Theme | Diagnosis of Biliary Tract Cancer -- Present Status and Perspective | |
|---|---|---|
| Title | Pathologic and Genetic Diagnosis of Biliary Tract Disease | |
| Publish Date | 2003/07 | |
| Author | Takao Itoi | Fourth Department of Internal Medicine, Tokyo Medical University |
| Author | Kazuto Nakamura | Fourth Department of Internal Medicine, Tokyo Medical University |
| Author | Atsushi Sofuni | Fourth Department of Internal Medicine, Tokyo Medical University |
| Author | Fumihide Itokawa | Fourth Department of Internal Medicine, Tokyo Medical University |
| Author | Kazuo Takei | Fourth Department of Internal Medicine, Tokyo Medical University |
| Author | Fuminori Moriyasu | Fourth Department of Internal Medicine, Tokyo Medical University |
| [ Summary ] | We assessed the sensitivity of pathologic and genetic diagnosis in patients with cholangiocarcinomas. The sensitivity of bile aspiration pathology, brushing cytology and biopsies, and genetic analysis by K-ras, p53, telomerase and hTERT was approximately 50%. However, recent progress in new devices and molecular biology may lead to the sensitivity of each method being raised. Moreover, we hope that pathologic and genetic diagnoses will be taken one step further for patients with poorly prognostic cholangiocarcinomas. | |