| [ Summary ] |
Brain-gut peptides, which are the main mediators of brain-gut interaction, control gastrointestinal motility, gastric acid secretion, visceral sensitivity, mental status, etc. In addition, some peptides are involved in immune responses to Helicobacter pylori, so they may be participating in the pathogenesis of NUD. Especially, since CCK, serotonin (mono amine), and opioids abundant in the central and enteric nervous systems are important regulators of gastrointestinal motility and visceral sensitivity, attention has been paid to these factors in patients with NUD. We review the recent knowledge of brain-gut peptides involved in the pathophysiology of NUD, focusing on these three peptides. |