| Theme | Current Topics on The Treatment for Esophageal Cancer | |
|---|---|---|
| Title | Definitive Chemoradiotherapy for Esophageal Cancer | |
| Publish Date | 2003/10 | |
| Author | Kei Muro | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Tatsuhiro Arai | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Takashi Ura | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Ayumu Goto | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Hisaaki Yasui | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Tetsuya Hamaguchi | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Yasuhide Yamada | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Yasuhiro Shimada | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Kuniaki Shirao | Division of Gastrointestinal Oncology, National Cancer Center Hospital |
| Author | Hiroyasu Igaki | Department of Surgery, National Cancer Center Hospital |
| Author | Yuji Tachimori | Department of Surgery, National Cancer Center Hospital |
| Author | Hoichi Kato | Department of Surgery, National Cancer Center Hospital |
| Author | Yoshinori Ito | Division of Radiation Oncology, National Cancer Center Hospital |
| Author | Atsushi Imai | Division of Radiation Oncology, National Cancer Center Hospital |
| Author | Yoshikazu Kagami | Division of Radiation Oncology, National Cancer Center Hospital |
| [ Summary ] | Recently, we have reported that the survival rates from definitive chemoradiotherapy (CRT) are comparable with those of surgical procedures for esophageal cancer in every clinical stage. Definitive CRT for esophageal cancer is a very attractive treatment, considered to be a cureoriented therapy and preserve the esophagus. However, up to this time, the number of cases and the long-term data on CRT are very limited and the analysis of CRT has only been available from retrospective studies in mono-institution, Therefore, the results of this treatment are not reliable. Further more, long-term toxicity after definitive CRT has became known as a serious problem. Preventing long-term toxicity, which is occasionally fatal, and providing a suitable treatment are both necessary. In the future, subjects for improvement in the survival rates for CRT are managing long-term toxicity and confirming salvage surgery including endoscopic mucosal resection (EMR), as a safe and reliable procedures for residual or recurrent disease after definitive CRT. It is necessary for us to have a much experience as possible with CRT in our clinical practices and in prospective clinical trials (e.g. the study of Japan Clinical Oncology Group). If this is done, we can understand the effect of CRT in comparison with surgery for esophageal cancer. |
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