| Theme | Pepsinogen -- Basic, Clinical Implications, and Epidemiology | |
|---|---|---|
| Title | Pepsinogens and Their Relation to Gastroduodenal Diseases Other than Gastric Cancer | |
| Publish Date | 2002/10 | |
| Author | Koji Sumii | Saiseikai Hiroshima Hospital |
| [ Summary ] | Serum pepsinogen I (PG I) levels are related to gastric acid secretion. A marked increase in PG I was noted in patients with duodenal ulcers, gastroduodenal ulcers or gastric ulcers (antrum). A marked decrease was noted in patients with pernicious anemia, gastric cancer, adenoma and gastric polyps. Pepsinogens were useful as markers for ulcer diathesis. In familial studies, hyper-PG I was considered to be a subclinical marker for duodenal ulcer diathesis, and the RFLP of PGC (PG II) was suggested as a genetic marker for gastric ulcer (body) diathesis. PG I levels were suitable markers for selecting patients at high risk for duodenal ulcer recurrence. The recurrence rates for duodenal ulcers was high in patients with hyper-PG I, and low for patients with low-PG I. It was the same in gastric ulcer cases. Serum pepsinogen levels of those were affected by H.pylori infections, were useful as subclinical markers only in patients who did not receive eradication therapy for H.pylori. |
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