| Theme | Gastrointesinal Submucosal Tumor -- Advances in the Diagnosis and Treatment | |
|---|---|---|
| Title | Molecular Biological Approach to GIST -- Recent Advancement of Genetic Abnormality of GIST | |
| Publish Date | 2001/03 | |
| Author | Toshihiko Doi | Department of Internal Medicine, National Shikoku Cancer Center Hospital |
| Author | Hisao Tajiri | Department of Clinical Research, National Shikoku Cancer Center Hospital |
| Author | Hiroya Imaoka | Department of Internal Medicine, National Shikoku Cancer Center Hospital |
| Author | Tomohiro Nishina | Department of Internal Medicine, National Shikoku Cancer Center Hospital |
| Author | Takashi Terao | Department of Internal Medicine, National Shikoku Cancer Center Hospital |
| Author | Hisashi Endo | Department of Internal Medicine, National Shikoku Cancer Center Hospital |
| Author | Ichinosuke Hyodo | Department of Internal Medicine, National Shikoku Cancer Center Hospital |
| [ Summary ] | The general concept of gastrointestinal submucosal tumors was changed greatly by the revelation of the origin of gastrointestinal stromal tumors (GIST). The mechanism of GIST formation is revealed by the presence of c-kit genomic mutations. However, we can not explain the malignant behavior or, metastatic qualities on c-kit genetic mutation only. Because abnormalities in the p53 gene, the INK4 family gene, telomerase associated gene are also involved in GIST. As in other malignant tumors, many kinds of genetic abnormalities may induce the complicated biological behavior of GIST, with their ability for multipotential differentiation. | |