| Theme | Endoscopic Diagnosis of Helicobater pylori Infection | |
|---|---|---|
| Title | Significance of Hemoglobin Index in Diagnosis of Helicobacter pylori Infection and Future Developments in Color Imaging to Detect Super Minute Cancers | |
| Publish Date | 2001/10 | |
| Author | Shigeru Asaki | Department of Internal Medicine, Division of Gastroenterology, Tohoku University School of Medicine |
| Author | Shigemitsu Aida | Department of Internal Medicine, Division of Gastroenterology, Tohoku University School of Medicine |
| [ Summary ] | Color images of gastric mucosa are thought to display the level of mucosal hemoglobin density. Gastric mucosal hemoglobin indicates the correlation between extracted G-signal (Vg) and R-signal (Vr). Vg reflects around 560nm rays from absorbed hemoglobin and Vr reflects around 650nm rays from unmodified hemoglobin. Extracting Vg and Vr to transform the logarithm for the ratio of Vr to Vg makes it possible to evaluate the hemoglobin index (IHb). We studied the diagnostic value of the mucosal IHb for Helicobacter pylori (HP) infection in the non atrophic fundic gland area of the upper body posterior wall of the stomach, which is about 1cm in size. We determined the cut-off index is 62 for the diagnosis of HP infection in our university trials. These showed a sensitivity of 93.3% and a specificity of 80%. About the same results were obtained in our related institution, with sensitivity of 90.9% and specificity of 84.2%. The index of IHb showed some differences in each institution, but the cause of this difference is uncertain. IHb may be a simple, sensitive and highly specific method to diagnose HP infected gastric mucosa. Moreover, we conducted tests to using colors divided 16 equal parts, ranging between 36.5 IHb value at the lowest being blue, with a 90.0 IHb value and the highest being red. The real time coloring method is very useful in diagnosing minute mucosal lesions, especially minute gastric cancer and its lateral invasion. A trial to determing mucosal hemoglobin values by routine endoscopic observation or coloring, according to IHb levels, might allow us in the near future to improve G-I endoscopic diagnosis, especially in the diagnosis of super minute gastric cancers. |
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