| Theme | Endoscopic Diagnosis of Helicobater pylori Infection | |
|---|---|---|
| Title | The Application of Measurement of Mucosal Hemoglobin Index in Endoscopic Diagnosis of Helicobacter pylori Infection -- Basis of Measurement of Mucosal Hemoglobin Index and Its Pathophysiological Significance | |
| Publish Date | 2001/10 | |
| Author | Takashi Nakamura | 3rd Department of Medicine, Teikyo University School of Medicine, Ichihara Hospital |
| Author | Koji Yakabi | 3rd Department of Medicine, Teikyo University School of Medicine, Ichihara Hospital |
| Author | Hiroki Tomono | 3rd Department of Medicine, Teikyo University School of Medicine, Ichihara Hospital |
| Author | Kazunori Asai | 3rd Department of Medicine, Teikyo University School of Medicine, Ichihara Hospital |
| Author | Shinko Kato | 3rd Department of Medicine, Teikyo University School of Medicine, Ichihara Hospital |
| Author | Susumu Kurosawa | 3rd Department of Medicine, Teikyo University School of Medicine, Ichihara Hospital |
| [ Summary ] | Helicobacter pylori (Hp) infection induces reddening (hyperemia) of the gastric fundic gland mucosa, and its erradication reduces this finding. On the basis of this phenomenon, endoscopic measurement of hemoglobin concentration in the fundic mucosa was studied as to whether it was effective as an endoscopic diagnostic tool for Hp infection, and its usefulness was confirmed. This paper discussed details of the technical problems with this method. The increasing mucosal hemoglobin index (IHb) in Hp infection is a reflection of the abnormal mucosal microcirculation (congestion). This abnormality derives from increased mast cells in Hp-infected gastric mucosa and this induces the increased release of vasoactive factors, especially histamine, from mast cells. Moreover, Hp infection increases the content of interleukin-8 (IL-8) in the gastric mucosa, and IL-8 also increases the release of histamine from mast cells. This seems to be the mechanism of mucosal IHb increase in Hp-infected fundic mucosa. |
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