| Theme | Mucosal Immune System of the Digestive Tract -- Recent Topics | |
|---|---|---|
| Title | Mucosal Immunity and Oral Vaccination | |
| Publish Date | 2000/03 | |
| Author | Yasuhiko Tabata | Institute for Frontier Medical Sciences, Kyoto University |
| [ Summary ] | Following oral injection of biodegradable microspheres(MS) containing an antigen into mice, both serum IgG antibodies and gut secretory IgA antibodies were enhanced, in contrast to free antigen injections. The profile of antibody production depended on the MS size. This dependence could be explained in terms of the Peyer's patch uptake of MS and the subsequent body distribution of MS. The same enhanced antibody production was also achieved even after rectal injection of the antigen-containing MS. In addition, the MS containing an anti-inflammatory drug exhibited superior therapeutic effects on inflammatory bowel disease(IBD). These findings indicate that a DDS system based on MS is promising for mucosal vaccinations as well as IBD therapy. | |