| Theme | Up-to-date Therapuetic Strategy for Advanced Colorectal Cancer | |
|---|---|---|
| Title | State of Art in Molecular Diagnosis for Aggressiveness in Colorectal Cancer | |
| Publish Date | 2000/11 | |
| Author | Ichiro Takemasa | Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University |
| Author | Shoji Nakamori | Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University |
| Author | Morito Monden | Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University |
| [ Summary ] | The aggressiveness of cancer has been evaluated in relation to several morphological factors. These factors, however, have many limitations and are not always justified to predict patients' prognosis and to personalize patients' treatment plans. Recent advances in molecular biology and cellular biology encourage us to evaluate colorectal cancer aggressivenes at the molecular level. We reviewed recent publications concerning molecular applications for prognostic markers of colorectal cancer. We also introduced a DNA array system to help us understand colorectal cancer aggressiveness more precisely. A molecular approach, using a DNA array system, could be one of the most useful tools to evaluate colorectal cancer aggressiveness and to select appropriate treatment strategies for colorectal cancer patients in the future. | |