| Theme | Laser Endoscopy in Theory and Practice --Perspective of GI Endoscopy in the 21st Century | |
|---|---|---|
| Title | Fluorescent Diagnosis of Cancer Using a 5-ALA | |
| Publish Date | 1999/07 | |
| Author | Norio Miyoshi | Department of Pathology, Fukui Medical University |
| [ Summary ] | 5-aminolevulinic acid (5-ALA) is a precursor in the heme biosynthetic pathway, from which protoporphyrin-IX(Pp-IX) is derived. This is a tumor-localizing photosensitizer for photodynamic therapy of cancer patients. Within four hours from time of i.v.-injection or oral administration, it is possible to easily find the Pp-IX red fluorescence emission from the limited brain tumors by using a blue light and it is possible to excise the tumor tissues during an operation. Unfortunately, although it is not yet possible to introduce the positive fluorescence-diagnosis into the endoscopic diagnosis using the 5-ALA, it will be useful to introduce the 5-ALA-derived Pp-IX fluorescence method into endoscopic diagnosis. I will be introduce you to the 5-ALA-derived Pp-IX fluorescence method, especially, the fluorescence spectroscopic properties and their applications for endoscopic diagnosis in this chapter. |
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