| Theme | NSAID and GI tract | |
|---|---|---|
| Title | Proton Pump Inhibitor and Healing of Nonsteroidal Anti-inf-lammatory Drug-associated Ulcers and Erosions | |
| Publish Date | 1999/04 | |
| Author | Katsushi Watanabe | First Department of Internal Medicine, Nagoya City Univercity |
| Author | Makoto Itou | First Department of Internal Medicine, Nagoya City Univercity |
| [ Summary ] | Ulcers and erosions of the stomach are extremely common in patients taking nonsterodial antiinflammatory drugs (NSAIDs). There have been few valid studies on the treatment of NSAIDs-associated peptic ulcers. Thhere is data to support that NSAIDs treatment should be stopped, if possible, while attemp-ting to heal ulcers. However, It is not always easy for patie-ntswith inflammatory conditions to do without their NSAID therapy. Sveral trials reported that the gastric ulser recovery rate for those treated with ranitidine or misoprostol av-ereged about 70% which is much higher than the placebo recovery rate of approximatery 20%, for NSAIDs-associated ulsers. Also, the recovery rate for those reciving omeprazole was higer compared to patients taking ranitidine or misopropostol for the same period. | |