| Theme | Precancerous Lesions in the Digestive System | |
|---|---|---|
| Title | Barrett's Esophagus and Precancerous Lesion | |
| Publish Date | 1998/06 | |
| Author | Takayuki Nishi | Department of Surgery, Tokai University, School of Medicine |
| Author | Hiroyasu Makuuchi | Department of Surgery, Tokai University, School of Medicine |
| [ Summary ] | It is well known that Barrett's epithelium is the result of chronic injury which is usually caused by gastroesophageal reflux. Adenocarcinoma in Barrett's esophagus is believed to develop through the metaplasia-dysplasia-carcinoma sequence. More recently, several studies focused on the involvement of p53 mutation in the process of malignant degeneration of Barrett's esophagus. The columner epithelium of Barrett's esophagus has a malignant predisposition, and once the diagnosis is made, periodic endoscopy with biopsy and cytologic study is indicated. |
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