| Theme | Malignant Lymphoma of the GI Tract | |
|---|---|---|
| Title | Gastric Lymphoma and Helicobacter pylori | |
| Publish Date | 1998/03 | |
| Author | Tadao Bamba | Department of Internal medicine, Shiga University of Medical Science |
| [ Summary ] | Lymphoid tissue is acquired in the stomach in response to antigenic stimulation, so called mucosa-associated lymphoid tissue (MALT). In 1983, Isaacson named a type of malignant B-cell lymphoma "MALT lymphoma". This form grows in the marginal zone of lymphoid follcles in the gastric mucosa. MALT lymphoma has lately attracted attention because of its relation to Helicobacter pylori (Hp). There are several studies showing that Hp can be detected in more than 90% of patients with MALT lymphoma and cure of Hp infection is followed by a complete regression of these tumors in most patients. This paper reviews the current knowledge of MALT lymphoma, and immunological and molecular aspects of the pathogenesis of this disease. |
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