| Theme | Malignant Lymphoma of the GI Tract | |
|---|---|---|
| Title | Multiple Lymphomatous Polyposis(MLP) and Adult T-cell Leukemia (ATL) | |
| Publish Date | 1998/03 | |
| Author | Takuji Gotoda | National Cancer Center Hospital, Department of Gastroenterology |
| Author | Hajime Yamaguchi | National Cancer Center Hospital, Department of Gastroenterology |
| [ Summary ] | We report gastroenterological findings of patients with multiple lymphomatous polyposis (MLP). We have also revealed gastrointestinal appearances of patients with adult T-cell leukemia (ATL) showing gastrointestinal involvement. These findings were fundamentally attributable to infiltration of tumor cells. Especially, the large intestinal appearance of ATL was similar to that of MLP. In addition, we reviewed the domestic literature. In order to establish the disease entity of MLP advocated by Cornes and define its relation to other tumors of the lymphatic system, "neoplastic proliferation of lymphatic cells causing polyposis-like changes in an extensive area of the gastrointestinal tract" should be treated as MLP in a broad sense. Thereby cases in which disease staging and clinicopathological as well as immunological examinations are adequately performed would accumulate. With the increasing use of colonoscopy, cases with this disease limited to the gastrointestinal tract may be found more frequently. In addition, histopathological and immunohistochemical examinations using large biopsy specimens should be routinely done to determine the benign or malignant nature of the disease. |
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