| Theme | Direction of the Prescription for Gastrointestinal Tract | |
|---|---|---|
| Title | Anti Ulcer Drugs Act on the Gastrointestinal Hormones | |
| Publish Date | 1998/12 | |
| Author | Toru Maekawa | Department of Internal Medicine, Kanebo Memorial Hospital / Department of Gastroenterology and Hepatology, Kyoto University School of Medicine |
| Author | Tsutomu Chiba | Department of Gastroenterology and Hepatology, Kyoto University School of Medicine |
| [ Summary ] | Histamine, acetylcholine and gastrin stimulate gastric acid secretion, whereas, somatostatin, prostaglandin and EGF/TGF-alpha inhibit the secretion. Many anti uicer drugs act on these gastrointestinal hormones. Presently, histamine receptor antagonists and proton pump inhibitors are the main drugs used for the inhibition of acid secretion. However, CGRP and new anti gastrin drugs are considered to produce good results in the treatment of ulcers. | |