| Theme | Hepatocarcinogenesis --Mechanism and Prevention | |
|---|---|---|
| Title | Chemoprevention of Second Primary Hepatoma by Acyclic Retinoid | |
| Publish Date | 1998/09 | |
| Author | Yoshimune Shiratori | First Department of Internal Medicine, Gifu University School of Medicine |
| Author | Hisataka Moriwaki | First Department of Internal Medicine, Gifu University School of Medicine |
| [ Summary ] | The effects of retinoids on hepatocarcinogenesis are controversial in experimental animal tests, depending on the affinity of retinoid ligands to nuclear retinoid receptors, such as retinoic acid receptors and retinoid X receptors. Acyclic retinoid (polyprenoic acid), is one of the retinoid X receptor ligands, inducing differentiation of human hepatoma-derived cell lines and inhibiting chemically-induced liver cancer in rats, as well as spontaneous hepatoma in mice. A randomized controlled clinical trial demonstrated the preventive effects of the compound on the development of second primary tumors in patients with hepatocellular carcinoma. This effect is exerted by the deletion of premalignant or malignant clones by the retinoid. Clinical experiences and the basic mechanisms of retinoids for chemoprevention of hepatorna are reviewed. | |