| Theme | Hepatocarcinogenesis --Mechanism and Prevention | |
|---|---|---|
| Title | Growth Factors and Growth Inhibitory Factors in Hepatocarcinogenesis | |
| Publish Date | 1998/09 | |
| Author | Sumio Kawata | Second Dapartment of Internal Medicine, Osaka University Medical School |
| [ Summary ] | The molecular mechanisms for hepatocarcinogenesis still remain to be determined. Liver regeneration is well-controlled by the exqusite regulation of gene expression of growth factors and growth inhibitory factors. However, this regulation seems to be altered in chronic hepatitis and liver cirrhosis. The deregulation of gene expression results in an acceleration of hepatocye growth cases of the chronic liver disease, leading to hepatocarcinogenesis, via an accumulation of gene abnormalities. We hypothesized that escape from growth inhibitory regulation by TGF-beta plays an important role in the accelerated growth of the hepatocytes. | |