| Theme | Kampo Medicine : New Trends in GI Therapoitics | |
|---|---|---|
| Title | Pentagalloylglucose, an Inhibitor of H+,K+-ATPase Purified from Hog Stomach | |
| Publish Date | 1997/07 | |
| Author | Kouichi Ono | The Third Dept. of Internal Medicine, Nihon University, School of Medicine |
| Author | Ariyoshi Iwasaki | The Third Dept. of Internal Medicine, Nihon University, School of Medicine |
| [ Summary ] | We purified a compound with a strong inhibitory effect on H+, K+-ATPase from Paeoniae Radix, which has been used in Japan for the treatment of gastritis and peptic ulcers. The compound was identified as 1,2,3,4,6,-Penta-O-galloyl-bete-D-glucose by proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, and fast atomic bombardment mass spectrometry. Pentagalloylglucose also inhibited the accumulation of [14C] aminopyrine in parietal cells isolated from the guinea pig stomach and then stimulated with 10microM histamine (IC50 7.8 /microM) and 1 mM dbc-AMP (IC50 10microM). These results suggest that pentagalloylglucose is a potent inhibitor of H+, K+-ATPase and may be responsible for the inhibition of acid secretion by Paeoniae Radix. | |