| Theme | Current Topics in Hepatitis viruses | |
|---|---|---|
| Title | Buoyant Densities of Blood-borne Hepatitis C Virus Particles | |
| Publish Date | 1997/05 | |
| Author | Masaaki Korenaga | First Department of Internal Medicine, Yamaguchi University, School of Medicine |
| Author | Keisuke Hino | First Department of Internal Medicine, Yamaguchi University, School of Medicine |
| [ Summary ] | Hepatitis C virus(HCV) exists in blood as circulating particles with different buoyant densities. Low density particles are thought to be highly infectious and to contain intact virions. High density particles contain nucleocapsid protein or virus-antibody complexes. Thus, the clinical significance of HCV particles of different buoyant densities is gradually becoming clear. We discuss herein the significance of analyzing these issues : [1. relative numbers of low and high density HCV particles in blood.] [2. hypervariable region (HVR) 1 quasispecies of immune complex or non-immune complex particles.] | |