| Theme | Current Topics in Hepatitis viruses | |
|---|---|---|
| Title | Association between Type A Severe Hepatitis and Hepatitis A Virus RNA | |
| Publish Date | 1997/05 | |
| Author | Kei-ichi Fujiwara | First Department of Medicine, Chiba University School of Medicine |
| Author | Osamu Yokosuka | First Department of Medicine, Chiba University School of Medicine |
| [ Summary ] | Patients with sporadic hepatitis A (HA), especially severe cases, have not been rare to date. Thus, we have analyzed the clinicopathological features of these HA patients and the relationship with hepatitis A virus (HAV) RNA.The proportion of sporadic HA, especially severe cases, was found to be increasing without significant differences in patient backgrounds. Furthermore, a significant correlation between clinicopathological features of HA and nucleotide sequences of the 5' nontranslated region of HAV was observed, suggesting that strain difference plays a role in the severity of HA. | |