| Theme | Duodenal Tumors | |
|---|---|---|
| Title | Carcinoid Tumor of the Duodenum | |
| Publish Date | 1997/04 | |
| Author | Yoshi Nagahata | First Department of Surgery, Kobe University School of Medicine |
| Author | Yoichi Saitoh | First Department of Surgery, Kobe University School of Medicine |
| [ Summary ] | Carcinoids are epithelial malignant tumors which invade into the submucosa or deeper layers of the digestive tract. Carcinoids should be referred to as gut-endocrinoma in order to include the few carcinoids which are histologically benign and have capsules in extragastrointestinal organs such as the lung and pancreas. Carcinoids of the duodenum are occasionally accompanied by synchronous malignant tumors or von Recklinghausen's disease. The majority of tumors are located in the first and second portions of the duodenum. Nearly half of the tumors are 10mm or less in size and often involve the submucosa of the duodenum. Manifestations of carcinoid syndrome are present in only 3% of patients with carcinoid of the duodenum. The definite diagnosis is made on the basis of histopathological findings, in which histologic types, silver impregnations and electronmicroscopic evaluation of endocrine granules in the neoplastic cells are considered important. Based on the general agreement concerning the above concepts, patients with carcinoids exceeding 16mm should usually undergo radical resection with D2 dissection of lymph nodes. | |