| Theme | Uremia and bone | |
|---|---|---|
| Title | Changes in type 1 collagen and bone material properties with chronic kidney disease | |
| Publish Date | 2019/01 | |
| Author | Akiko Tajiri | Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| Author | Taketo Uchiyama | Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| Author | Ichiro Ohkido | Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| [ Summary ] | The mechanisms related to bone fragility in patients with chronic kidney disease (CKD) are widely known, and the causes of bone fragility are diverse. Among those causes, it is a very interesting concept that bone fragility in patients with CKD is caused by changes in bone material characteristics resulting from changes of type 1 collagen. There are two types of collagen crosslinking. One is "enzyme-dependent crosslinking". The other is "advanced glycation-product crosslinking". Renal dysfunction causes a decrease in enzyme-dependent crosslinking, whereas there is an increase in advanced glycation-product crosslinking. The causes of these changes in collagen crosslinking, such as accumulation of uremic toxins, hyper-homocysteinemia, vitamin D activation disorders, and enhancement of oxidative stress, have been reported. In this article, we will describe how renal dysfunction causes changes in type 1 collagen and bone material properties in terms of changes in collagen crosslinking. | |