| Theme | Uremia and bone | |
|---|---|---|
| Title | Bone metabolism and related preferential c-axis orientation of apatite cr ystallites | |
| Publish Date | 2019/01 | |
| Author | Ryosuke Ozasa | Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University |
| Author | Takuya Ishimoto | Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University |
| Author | Takayoshi Nakano | Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University |
| [ Summary ] | Apatite is an important component of the bone matrix as well as collagen and non-collagenous proteins because apatite contributes to stiffen bone. Preferential orientation of the apatite c-axis is a vector that describes "direction and magnitude" of the ionic arrangement of apatite crystals, while bone mineral density describes mineral quantity. Therefore, orientation expresses the anisotropic nature of the bone matrix, in contrast to bone mineral density. The orientation is closely associated with bone metabolism. On the other hand, uremia alters orientation via bone metabolism-unrelated mechanism. In this review, the significance of apatite c-axis orientation is explained and the relation of bone metabolism and uremia to apatite c-axis orientation is introduced based on our recent findings. | |