| Theme | Lifestyle-related diseases and fracture risk | |
|---|---|---|
| Title | Poor bone quality in patients with diabetes, arteriosclerosis, or chronic kidney disease | |
| Publish Date | 2010/01 | |
| Author | Mitsuru Saito | Department of Orthopaedic Surgery, Jikei University School of Medicine |
| [ Summary ] | Arteriosclerosis and diabetes lead to deterioration of bone quality in terms of collagen cross-links formation of bone. Hyperglycemia, oxidative stress, and hyperhomocysteinemia induce the reduction in benefi cial enzymatic cross-links and the accumulation of disadvantageous nonenzymatic cross-link, as well as advanced glycation end products (AGEs) in bone. In this review, I describe that diabetes and hyperhomocysteinemia are crucial determinants of detrimental crosslinking of bone collagen which have been reported in medical literature. | |