Clinical Gastroenterology Vol.33 No.13(8)

Theme Liver Fibrosis : Beyond the Diagnosis
Title Recent Development and Future Prospects of Therapy Targeting Liver Fibrosis Regression and Liver Regeneration
Publish Date 2018/12
Author Atsunori Tsuchiya Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
Author Masahiro Ogawa Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
Author Shunsuke Nojiri Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
Author Takayuki Watanabe Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
Author Suguru Takeuchi Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
Author Shuji Terai Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
[ Summary ] Previously, liver cirrhosis was thought to be irreversible. However, recently a great deal of evidence has indicated that liver cirrhosis is reversible after anti-viral therapy using direct acting antivirals for the hepatitis C virus and nucleotide analogue for the hepatitis B virus. Furthermore basic studies and clinical studies targeting regression of fibrosis are ongoing. In this section, we will introduce the recent basic and clinical study targeting fibrogenesis and fibrolysis.
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