| [ Summary ] |
Development of chronic kidney disease (CKD) increases risks for falls and bone fracture as well as morbidity of sarcopenia and frailty. Since protein energy wasting (PEW) plays a pivotal role in the pathogenesis, nutritional status may determine the prognosis among CKD patients. On the other hand, CKD-mineral and bone disorder (MBD) leads to mineral and hormonal abnormalities, bone metabolic change, and vascular calcification, affecting mortality as well as morbidity of cardiovascular disease. This evidence suggests that total management including PEW and CKD-MBD is required in medical treatment for CKD patients. This review will focus on current hot topics such as secretory mechanisms of phosphaturic hormones, their biological action on the skeletal muscle, and pathophysiology of sarcopenia in CKD. |