| Theme |
Endocrinological control of bone metabolism |
| Title |
Roles of myokines such as osteoglycin in bone metabolism |
| Author |
Naoyuki Kawao |
Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine |
| Author |
Hiroshi Kaji |
Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine |
| [ Summary ] |
Interactions between the muscle and bone have been noted as a common mechanism of sarcopenia and osteoporosis. Increasing evidence suggests that various myokines released from the skeletal muscles affect bone metabolism. Myostatin, a negative regulator of muscle mass, decreases bone mass by enhancement of osteoclast formation and suppression of osteoblast differentiation. Follistatin, an endogenous antagonist of myostatin, might contribute to the regulation of muscle and bone by gravity change. Although irisin released from muscle during exercise increases bone mass in mice, it has recently been reported to be related to ovariectomy-induced osteoporosis through osteocytic osteolysis. Osteoglycin seems to function as a negative regulator of bone metabolism. Further studies of myokines in muscle/bone relationships may lead to the development of a novel therapeutic drug for both sarcopenia and osteoporosis. |