腎と骨代謝 Vol.32 No.2(2-2)


特集名 ホルモンによる骨代謝の制御
題名 骨の成長・成熟・老化とホルモン (2) 甲状腺ホルモンと甲状腺刺激ホルモン
発刊年月 2019年 04月
著者 鬼形 和道 島根大学医学部附属病院卒後臨床研修センター／島根大学医学部附属病院小児科
【 要旨 】 甲状腺ホルモンは，骨格系の成長，骨塩量の獲得，および骨リモデリングに関わる．活性型甲状腺ホルモン（T3）の骨格系に対する作用は，おもに甲状腺ホルモン受容体α（TRα）を介する．甲状腺ホルモン作用不全は，小児期では骨成熟遅延を伴う成長障害をきたし，成人期では骨リモデリング障害と骨折リスクの上昇をもたらす．
Theme Endocrinological control of bone metabolism
Title Role of the thyroid hormone and TSH in skeletal development and bone maintenance
Author Kazumichi Onigata Postgraduate Clinical Training Center, Shimane University Hospital / Department of Pediatrics, Shimane University Faculty of Medicine
[ Summary ] The skeleton is a tissue sensitive to the thyroid hormone. An active thyroid hormone (triiodothyronine, T3) has a critical role in linear growth during development and adult bone turnover and maintenance. The functions of the thyroid hormone on skeletal cells are mainly mediated by thyroid hormone receptor alpha (THα). Hypothyroidism or reduced sensitivity to thyroid hormone causes delayed bone maturation and disturbed linear growth in children and altered bone turnover and increased risk of bone fracture in adults.
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