| Theme |
Uremia and bone |
| Title |
Changes in type 1 collagen and bone material properties with chronic kidney disease |
| Author |
Akiko Tajiri |
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| Author |
Taketo Uchiyama |
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| Author |
Ichiro Ohkido |
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| [ Summary ] |
The mechanisms related to bone fragility in patients with chronic kidney disease (CKD) are widely known, and the causes of bone fragility are diverse. Among those causes, it is a very interesting concept that bone fragility in patients with CKD is caused by changes in bone material characteristics resulting from changes of type 1 collagen. There are two types of collagen crosslinking. One is "enzyme-dependent crosslinking". The other is "advanced glycation-product crosslinking". Renal dysfunction causes a decrease in enzyme-dependent crosslinking, whereas there is an increase in advanced glycation-product crosslinking. The causes of these changes in collagen crosslinking, such as accumulation of uremic toxins, hyper-homocysteinemia, vitamin D activation disorders, and enhancement of oxidative stress, have been reported. In this article, we will describe how renal dysfunction causes changes in type 1 collagen and bone material properties in terms of changes in collagen crosslinking. |