| Theme |
Uremia and bone |
| Title |
Approaches for assessing of bone quality with molecular spectroscopy : infrared and Raman spectroscopy |
| Author |
Hiromi Kimura-Suda |
Department of Applied Chemistry and Bioscience, Faculty of Science and Technology, Chitose Institute of Science and Technology / Graduate School of Photonics Science, Chitose Institute of Science and Technology |
| Author |
Teppei Ito |
Graduate School of Photonics Science, Chitose Institute of Science and Technology |
| Author |
Yuya Kanehira |
Graduate School of Photonics Science, Chitose Institute of Science and Technology |
| Author |
Fumiya Nakamura |
Department of Applied Chemistry and Bioscience, Faculty of Science and Technology, Chitose Institute of Science and Technology |
| [ Summary ] |
Both bone quality and bone mineral density (BMD) contribute to bone strength. The definition of bone quality is ambiguous; however, BMD is the measured parameter of the bone weight per unit area (g/cm2). Bone quality is composed of multiple parameters such as microdamage, porosity, mini-modeling, mineral-to-matrix ratio, carbonate-to-phosphate ratio, mineral maturity, collagen cross-linking, orientation of collagen fiber and hydroxyapatite. Many of those parameters have not been well-organized. Both infrared (IR) and Raman spectroscopies are non-invasive analytical methods and give several bone quality parameters simultaneously in one measurement with good reproducibility, which makes other analytical techniques available from the same sample. Therefore, IR and Raman spectroscopies are powerful tools for the assessment of bone quality in a systematic manner. |