| Theme |
Progress in parathyroid research : Pathophysiology and treatment |
| Title |
New target tissues and functions of parathyroid hormone |
| Author |
Toru Maruyama |
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| Author |
Hiroshi Watanabe |
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| Author |
Motoko Tanaka |
Department of Nephrology, Akebono Clinic |
| [ Summary ] |
Recent studies demonstrate that the parathyroid hormone (PTH) not only maintains mineral homeostasis in the target tissues of the kidneys and bone, but also functions in other organs. For instance, PTH drives adipose tissue browning and cachexia, and induces urate accumulation through inhibiting the expression of the ABCG2 gene in both the small intestine and the kidney.
Interestingly, PTH exerts these novel actions through its receptor (PTHR). Therefore, it is possible to identify more novel functions of PTH in various organs that express PTHR. |