| Theme |
The impact of bone and mineral disorders on multiple diseases |
| Title |
Sodium and bone : hyponatremia and fractures |
| Author |
Yoshihisa Sugimura |
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine |
| [ Summary ] |
Hyponatremia is the most common electrolyte disorder observed in clinical practice. There is accumulating evidence that even mild hyponatremia is associated with increased morbidity and mortality. It has been reported that the gait instability associated with chronic hyponatremia causes falls, resulting in a higher frequency of bone fractures. We demonstrated that hyponatremia is associated with significantly increased odds of osteoporosis using cross-sectional human data and that hyponatremia markedly reduced bone mass via increased bone resorption using an SIADH rat model. In addition, we showed that sustained low extracellular sodium ion concentrations ([Na+]) directly stimulate osteoclastogenesis and that hyponatremia-induced oxidative stress is involved in the mechanism. |