| Theme |
Regeneration of bone and cartilage |
| Title |
Cartilage regeneration using chondrocyte transplantation |
| Author |
Naosuke Kamei |
Department of Orthopaedic Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University / Medical Center for Translational and Clinical Research, Hiroshima University Hospital |
| Author |
Nobuo Adachi |
Department of Orthopaedic Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University |
| Author |
Mitsuo Ochi |
Department of Orthopaedic Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University |
| [ Summary ] |
We established a regenerative therapy for the repair of articular chondral defects using three-dimensional chondrocyte culture. Chondrocytes are isolated from a small endoscopically harvested piece of cartilage. The cartilage-like tissues are prepared from three-dimensional cultures of these chondrocytes with atelocollagen and transplanted to articular chondral defects. After the technological transfer of this treatment to Japan Tissue Engineering Co., Ltd., a multicenter clinical trial provided sufficient evidence of its safety and efficacy. Our threedimensional cultured cartilage received government approval to be manufactured and sold as Autologous Cultured Cartilage JACC ® and covered by National Health Insurance of Japan in April 2013. As of May 2015, 147 medical facilities have been approved to use JACC. This treatment has been used throughout Japan. |