| Theme |
Regeneration of bone and cartilage |
| Title |
Local transplantation of peripheral blood stem cells for bone regeneration |
| Author |
Ryosuke Kuroda |
Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| Author |
Takahiro Niikura |
Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| Author |
Tomoyuki Matsumoto |
Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| Author |
Sangyang Lee |
Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| Author |
Masahiro Kurosaka |
Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| [ Summary ] |
Whereas most fractures typically heal, a significant proportion (5-10 %) of fractures fail to heal, resulting in delayed union or persistent nonunion. Nonunion of the long bone is a common problem that can be disabling. Treatment may require multiple operative procedures, prolonged hospitalization, and years of disability. Circulating CD34(+) cells, a population rich in endothelial cells and hematopoietic progenitor cells are capable of differentiating into both endothelial cells and osteoblasts. Transplantation of circulating CD34(+) cells provides a favorable environment for fracture healing via angiogenesis/vasculogenesis and osteogenesis, leading finally to functional recovery from fracture. Based on a series of basic studies, we performed a phase 1/2 clinical trial of autologous CD34(+) cell transplantation in patients with tibial or femoral nonunions and reported the safety and efficacy of this novel therapy. In this article, the current concepts and strategies of circulating CD34(+) cellbased therapy for bone repair will be highlighted. |