| Theme |
Pediatric bone : From fetus to adolescent |
| Title |
Use of induced pluripotent stem cells for modeling skeletal dysplasia |
| Author |
Noriyuki Tsumaki |
Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University |
| Author |
Akihiro Yamashita |
Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University |
| Author |
Minoru Okada |
Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University |
| [ Summary ] |
Difficulties in obtaining cartilage samples from patients with skeletal dysplasia have hampered the investigation of related pathomechanisms. The generation of induced pluripotent stem (iPS) cells, however, has enabled us to obtain chondrocytes and cartilage that recapitulate cartilage in patients with skeletal dysplasia. The result has been iPS cell disease modeling, which is accomplished by generating iPS cells from dermal fibroblasts or blood cells from patients and then differentiating them toward chondrocytes to create cartilage tissue. The resultant chondrocytes and cartilage have proven useful to study pathomechanisms and for drug screening. |