| Theme |
Clinical research in the field of CKD-MBD |
| Title |
Fractures and bone histomorphometry in CKD-MBD |
| Author |
Junichiro James Kazama |
Division of Blood Purification Therapy, Niigata UniversityMedical and Dental Hospital |
| [ Summary ] |
The two most common bone diseases observed in at the earliest eras of dialysis therapy were bone changes associated with severe hyperparathyroidism and osteomalacia. Tetracycline labeling-dependent bone histomorphometry has developed as the most precise method to diagnose these two disease conditions. Progress in medical therapies has dramatically decreased the occurrence of these two disease conditions. However, the risk of hip fractures per se is still considerably high in dialysis patients. The main background abnormality responsible for this condition is not systemic mineral metabolic disorders. Thus, we should recognize that histological examination is no longer the gold standard for diagnosing bone disease in dialysis patients. |