| Theme |
The multifaced role of bone for multisystem illness |
| Title |
Bone and nervous systems |
| Author |
Toru Fukuda |
Department of Physiology and Cell Biology, Tokyo Medical and Dental University Graduate School and Faculty of Medicine |
| Author |
Shu Takeda |
Department of Physiology and Cell Biology, Tokyo Medical and Dental University Graduate School and Faculty of Medicine |
| [ Summary ] |
The traditional view of bone metabolism as being primarily due to endocrine regulation has been expanded in recent years following the identification of the ability of the nervous system to control bone metabolism, as shown by leptin-deficeint animal studies. The sympathetic and parasympathetic nervous systems are seen to regulate bone formation and bone resorption. In addition, the sensory nervous system has also been shown to be involved in the regulation of bone homeostasis. These studies demonstrate that the nervous system is closely related to bone remodeling. New therapeutic drugs for bone disorders can be developed by elucidation of the role of the nervous system in bone metabolism. |