| 連載名 | Clinical Investigation | |
|---|---|---|
| 題名 | 介護・看護女性職員への天然ビタミンD投与はeGFR，HDL-C値を上げる | |
| 発刊年月 | 2014年 04月 | |
| 著者 | 桑原 隆 | 済生会茨木病院腎臓内科 |
| 著者 | 山田 佐知子 | 済生会茨木病院腎臓内科 |
| 著者 | 西口 健介 | 済生会茨木病院腎臓内科 |
| 著者 | 寒川 昌平 | 済生会茨木病院腎臓内科 |
| 著者 | 王 麗楊 | 済生会茨木病院腎臓内科 |
| 【 要旨 】 | 目的：介護・看護職員は日光に浴する機会が少なくビタミンD不足は深刻と思われる．介護・看護女性職員に天然ビタミンD（以下，nVD）を投与し，血液検査の変動を見た． 方法：老健施設（7名），茨木病院（9名）の女性職員（平均年齢46.1±7.1歳）にパンビタン® 1g（VD2 200 単位含有）を3カ月投与後，天然ビタミンD3 1,000単位（以下，D3）を週3回併用し，それぞれ投与前，投与後3カ月に採血した． 成績：パンビタン投与前，投与後3カ月，D3投与後3カ月の25OHVD濃度（ng/ml）はそれぞれ，19.5，21.9，31.9 とパンビタンでわずかに，D3併用で十分に上昇した．eGFR（ml/min）はそれぞれ，71.0，75.8，93.5で投与前に比しD3投与後有意に上昇した．HDL-C（mg/dl）はそれぞれ，67.1，70.3，69.8（n＝10）でパンビタン投与後有意に上昇し，D3内服継続した10名のパンビタン投与前HDL-C 63.1に比しD3投与後有意に上昇していた．LDL-C，TG，Ca，Pi値は変化を認めなかった． |
|
| Series | Clinical Investigation | |
|---|---|---|
| Title | Study indicating improved kidney function and HDL-C, with administration of native vitamin D | |
| Author | Takashi Kuwahara | Department of Nephrology, Saiseikai Ibaraki Hospital |
| Author | Sachiko Yamada | Department of Nephrology, Saiseikai Ibaraki Hospital |
| Author | Kensuke Nishiguchi | Department of Nephrology, Saiseikai Ibaraki Hospital |
| Author | Shouhei Soukawa | Department of Nephrology, Saiseikai Ibaraki Hospital |
| Author | Riiyan Wan | Department of Nephrology, Saiseikai Ibaraki Hospital |
| [ Summary ] | Individuals who work in medical institutions often have limited opportunities to be exposed to adequate levels of sunlight to generate innate levels of vitamin D. Subjects consisted of seven nursing home employees as well as nine nurses working in the Ibaraki Hospital. Mean subject age was 46.1 ± 7.1 years. Subjects were administered Panvitan ® at levels of 1g containing 200 IU of ergocalciferol over a period of three months. Native vitamin D3 (1,000 IU of cholecalciferol) was subsequently administered three times a week. Blood samples were obtained at time of each administration. Serum levels were 25OHVD (ng/ml) compared to levels of 19.5 before administration. Levels rose slightly to 21.9 with Panvitan administration, and up to 31.9 after D3 administration. Renal function, as reflected by eGFR (ml/min) levels was 71.0 at initiation of medication and rose to 75.8 after Panvitan administration. It subsequently rose to 93.5 with continued vitamin administration. Initial HDL-C (mg/dl) levels were 67.1, rising to 69.8. No changes were observed in LDL-C, TG, Ca or Pi values. These results confirm previous reports in which vitamin D was seen to reduce urinary protein levels, without causing adverse effects on kidney function in CKD patients, in addition to increased HDL-C and unchanged LDL-C levels. In conclusion, subjects with improved levels of 25OHVD exhibited improved kidney function and increased HDL-C levels. | |