| Theme |
Parathyroid diseases and their pathogenesis |
| Title |
Role of oxidative stress in CKD-MBD |
| Author |
Motoko Tanaka |
Department of Nephrology, Akebono Clinic |
| Author |
Hiroshi Watanabe |
Department of Biopharmaceutics, School of Pharmacy, Kumamoto University |
| Author |
Toru Maruyama |
Department of Biopharmaceutics, School of Pharmacy, Kumamoto University |
| Author |
Masafumi Fukagawa |
Department of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine |
| [ Summary ] |
Recent studies have shown that higher levels of protein-bounding uremic toxins such as IS are involved, not only with the progression of CKD but also with the development of CKD-MBD. Uremic toxins enter into cells through OATs in the kidneys, arteries, and bones. They induce various abnormalities through intracellular ROS production. Moreover, high levels of phosphorus and PTH also induce oxidative stress and promote vascular calcification related to CKD-MBD.
New strategies to reduce uremic toxins and oxidative stress will be expected for patients with CKD. |