| Theme |
Parathyroid diseases and their pathogenesis |
| Title |
Molecular pathophysiology in primary hyperparathyroidism |
| Author |
Yasuo Imanishi |
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| Author |
Masaaki Inaba |
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| [ Summary ] |
Primary hyperparathyroidism (PHPT) is due to excessive secretion of parathyroid hormone (PTH) by one or more parathyroid tumor, triggering hypercalcemia. Some genes have been identified not only as being associated with familial PHPT, but also non-familial diseases. In this review, these genes and their functions in the pathogenesis in PHPT are discussed. |